Abstract
Osteosarcoma is the most common bone primary malignant tumor and nearly 30% of patients still die from osteosarcoma due to metastasis or recurrence. Thus, it is necessary to develop effective new chemotherapeutic agents for osteosarcoma treatment. α-Mangostin is a xanthone derivative shown to have antioxidant and anticarcinogen properties. However, the molecular mechanisms underlying the antimetastatic effects of osteosarcoma remain unclear. In metastasis progression, epithelial mesenchymal transition (EMT) is a process that plays important roles in development, cell polarity, and increased invasion and migration. This study focused on the induction of apoptosis and inhibition of EMT process by α-mangostin in human osteosarcoma cell line MG63. α-Mangostin treatments on MG63 cells not only showed the several lines of evidence of apoptotic cell death but also inhibited cell migration, invasion, and EMT-inducing transcription factor. In conclusion, we demonstrate that the α-mangostin induces apoptosis via mitochondrial pathway and suppresses metastasis of osteosarcoma cells by inhibiting EMT.
Highlights
Osteosarcoma, which is highly malignant and the most common bone tumor, predominates among teenagers
The current study was designed to elucidate the effect of α-mangostin on MG-63 osteosarcoma cell apoptosis, epithelial mesenchymal transition (EMT), and the molecular mechanism
These results indicated that αmangostin induced apoptosis of MG-63 cells significantly 50 μM α-mangostin for 24 h
Summary
Osteosarcoma, which is highly malignant and the most common bone tumor, predominates among teenagers. Its prevalence is low relative to other cancers, it is fatal if not discovered early [1] It has several characteristics, including a rapid cell growth rate, high metastatic potential, and local infiltration to other organs [2, 3]. Α-Mangostin, one of the xanthones, has demonstrated anticancer activity against various cancer cell lines [7, 15,16,17,18]. During cancer progression and metastasis, a cell morphologic conversion process occurs known as an epithelial mesenchymal transition, which is a significant action. The current study was designed to elucidate the effect of α-mangostin on MG-63 osteosarcoma cell apoptosis, EMT, and the molecular mechanism
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