Abstract

1. The treatment of rats with propylthiouracil (PTU) resulted in an induction of not only cationic but also anionic glutathione (GSH) transferases. 2. DE-52 column chromatography of the anionie GSH transferases divided into five main peaks (I–V). 3. Peaks I–IV had a high activity toward l-chloro-2,4-dinitrobenzene (CDNB). Peak V, which is a new form of the enzyme, showed high activity to ethaerynic acid. 4. PTU induced peaks I and V, whereas phenobarbital increased the activity of only peak I.

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