Abstract
Background Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects. It is given traditionally in the form of multiple subcutaneous injections which makes the treatment inconvenient. Furthermore, systemic allergenadministration may cause severe side effects. Therefor the development of alternative routes for SIT has been a longsought goal. The aim of this study was to investigate if epicutaneous application of recombinant birch pollen allergen Bet v 1 (i.e., patch vaccination) can induce systemic allergen-specific IgG responses with protective activity.
Highlights
Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects
The aim of this study was to investigate if epicutaneous application of recombinant birch pollen allergen Bet v 1 can induce systemic allergen-specific IgG responses with protective activity
ELISA experiments were performed to measure the development of IgG specific for Bet v 1, Bet v 1-related pollen and food allergens (i.e., Aln g 1, Cor a 1, Mal d 1) and for unfolded Bet v 1 fragments
Summary
Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects. It is given traditionally in the form of multiple subcutaneous injections which makes the treatment inconvenient. Systemic allergenadministration may cause severe side effects. Therefor the development of alternative routes for SIT has been a longsought goal. The aim of this study was to investigate if epicutaneous application of recombinant birch pollen allergen Bet v 1 (i.e., patch vaccination) can induce systemic allergen-specific IgG responses with protective activity
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