Abstract
SUMMARY Epidermal aryl hydrocarbon hydroxylase activity of homogenates from mice treated for 7 days with various topical corticosteroid ointments was significantly higher than in preparations from animals receiving steroid-free ointment bases, or no treatment. As determined by 3,4-benzopyrene oxidation, enzyme activity was also greatly increased 24 h after small doses of various polycyclic hydrocarbons given by the intraperitoneal route. Inhibition of enzyme activity was observed in skin homogenates from both control and treated animals following addition in vitro of 7,8-benzoflavone, but not with dimethylsulphoxide.
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