Abstract
The effect of recombinant human granulocyte colony-stimulating factor (G-CSF) on induction of differentiation of mouse myeloid leukemic M1 cells was examined. Purified G-CSF caused dose-dependent induction of phagocytic activity and lysozyme activity in M1 cells. Its half-maximally effective concentration was 10 ng/ml. On treatment of M1 cells with G-CSF (100 ng/ml) for 4 days, 30–50% of the cells differentiated morphologically into macrophage cells; 30–40% of the cells were blast cells and 20–30% of the cells were forms intermediate between blastic cells and mature macrophages.
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