Abstract
Background The present study examined the functional roles of the prostaglandin D2 (PGD2) receptors in allergic and immune reactions in mouse. We previously cloned the gene for a G protein-coupled receptor named CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2) and revealed that CRTH2 functions as a receptor for PGD2 with preferential expression on Th2 cells, eosinophils and basophils in human. PGD2 is an arachidonic acid metabolite that has long been implicated in allergic and immune reactions. PGD2 exerts its activities by binding to PGD2 receptors (DP and CRTH2) on target cells.
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