Abstract
The effect of various inducers and inhibitors of drug-metabolizing enzyme systems was studied on the kinetics of apomorphine disappearance and of the appearance of apomorphine glucuronides. The generally claimed inducers, phenobarbital and testosterone, and inhibitors, β-diethylaminoethyl diphenylpropyl-acetate and actinomycin D, were found to have no significant effect on the metabolism of apomorphine. Estradiol, however, produced a significant inhibition of the metabolism. Apomorphine pretreatment for 3 days exhibited a definite induction of its own metabolism.
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