Abstract
Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protective activity. Inspired by these results, the active substructure of pentadienone and quinazoline were spliced to obtain curcumin analogs as potential exogenously induced resistant molecule. Bioassay results showed that compound A13 exhibited excellent protective activity for tobacco to against Tobacco mosaic virus (TMV) at 500 μg/mL, with a value of 70.4 ± 2.6% compared with control treatments, which was better than that of the plant immune activator chitosan oligosaccharide (49.0 ± 5.9%). The protective activity is due to compound A13 inducing tobacco resistance to TMV, which was related to defense-related enzymes, defense-related genes, and photosynthesis. This was confirmed by the up-regulated expression of proteins that mediate stress responses and oxidative phosphorylation.
Highlights
Tobacco mosaic virus (TMV) is a well-studied plant virus that causes massive crop loss.The prevention and treatment of TMV remain a problem worldwide [1]
The target compounds A1–A20 were synthesized with the intermediates 4-chloroquinazoline
Target compounds A1–A20 were synthesized with the intermediates 4-chloroquinazoline and
Summary
Tobacco mosaic virus (TMV) is a well-studied plant virus that causes massive crop loss. The prevention and treatment of TMV remain a problem worldwide [1]. Previous achievements in the prevention and treatment of plant virus diseases involved large doses of drugs, such as Ribavirin, Triacontanol, Benzo-(1,2,3)-thiadiazole-7-carbothiolic acid, which caused irreparable damage to the plants [2,3,4]. The relevant defense substances in plants that provide defense can resist viral invasion, inhibit viral proliferation in vivo, or confer self-protection. The defense process is extremely slow; it can be hastened by plant immune activators, which can boost pattern-triggered immunity (PTI) resulting in enhanced resistance against pathogens [6,7,8]
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