Abstract
Using the pregnant rat in which deciduomas were induced by injection of arachis oil into the uterus, it has been found that induced protein (IP) synthesis is greatly increased in the deciduomas. A similar increase was obtained in deciduomas induced in progesterone-maintained ovariectomized animals. The increased synthesis in the pregnant animals was not correlated either with levels of circulating estradiol or the concentration of nuclear estradiol receptor. Synthesis was generally correlated with the degree of cellular mitosis in the uterus. It is suggested that IP synthesis is suppressed in the uterus on Day 5 of pregnancy, but is released from suppression by the initiation of decidualization. It is also suggested that IP is involved in uterine cell division.
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