Abstract

The discovery of induced pluripotent stem cells (iPSCs) by Dr. Shinya Yamanaka and his team has opened up many avenues of research. This includes medical initiatives such as the Precision Medicine and Personalized Medicine initiatives to use patient-specific stem cells to guide medical professionals on the base courses of treatment for various disorders based on the patient's own genetic background, i.e., targeting the best treatment for the individual patient. However iPSC technology has greater potential than disease modeling and regenerative medicine therapies. In this chapter, we will outline how to culture and maintain human iPSCs, differentiate human iPSCs into neurons, and discuss how iPSCs can be utilized for developmental toxicology studies. Furthermore, this chapter will highlight a burgeoning field using iPSCs to examine personalized exposure risks.

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