Abstract
Regenerative medicine has an exciting role in the treatment of disorders and conditions where there is an irreversible damage to a tissue or an organ or in immunodeficient state. Stem cells which have the potential to differentiate into specific types of cells, offers a new concept of regenerative medicine to treat spectrum of diseases including infections. Infections are one of the cause of high morbidity during injuries and in immunodeficient states. Induced pluripotent stem cells (iPSCs) are generated by genetically reprogramming the adult cells to an embryonic stem cell (ESC)-like state by being forced to express genes and factors essential for maintaining the defining properties of ESC. In infections, eosinophils play an important role as they are potent source of cytotoxic mediators such as eosinophil cationic protein (ECP) and major basic proteins (MBP). These substances play an important role in immune response to infections caused by bacteria, viruses, parasites and in resistance to some forms of cancer. Strategies to enhance the intrinsic functional abilities of eosinophils by lineage specific differentiation of iPSC and enhanced expression of cytotoxic mediators by advanced genetic engineering approach provide important future application in such opportunistic infections.
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