Abstract
Scorpion envenomation is a serious public health issue.Androctonus mauretanicus(Am) andButhus occitanus(Bo) are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. This work achieved the first comparative pathophysiological and toxic-symptoms study between theAmandBovenoms from a biochemical, toxicological and physiopathological standpoint. The activity of venoms and their subletal dose were determined by administration of increasing concentrations of the venoms. 30, 60 and 120 min following the experimental envenomation in mice, the profile of clinical symptoms was underlined and the main organs: brain, heart, lungs, liver and kidneys were removed for histological examination. TheAmvenom is a rich source of proteins and three-times more toxic than theBo. The most observed clinical symptoms are neurological and cardiopulmonary. TheAmvenom caused histopathological alterations at 30, 60, and 120min which were more important than theBo. This study highlighted that both venoms exhibited a strong toxicity with variable intensities. Moreover, we showed the presence of correlation between the level of histopathological disorders observed and the intensity of signs appeared at the same time following venom inoculation.
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