Abstract
The electrochemical behavior of pyridoxine was studied in 0.1 mol × L−1 NaX (X = F, Cl, Br) support electrolyte on a gold electrode using cyclic voltammetry and UV–Vis spectrophotometry. The influence of gold nanoparticles (AuNPs) on the electrochemical behavior of pyridoxine was studied. The experimental results obtained by both cyclic voltammetry and UV–Vis spectrophotometry indicate strong interactions in the B6 and NaBr/NaCl_AuNP systems, while in the NaF_B6_AuNP ternary system the results indicate a mechanism of direct electrochemical degradation of vitamin B6. The experimental results obtained for the electrochemical degradation of pyridoxine, in the presence of chloride and bromide ions, indicate strong interactions in the NaCl_B6_AuNP and NaBr_B6_AuNP systems associated with the spectrophotometric identification of the electrogenerated intermediates, while in the presence of fluoride ions no such products are identified. The development of the mechanism of electrochemical degradation of the pyridoxine molecule predicts both the formation of the corresponding electrogenerated intermediates and the steps of electro-incineration in a direct mechanism.
Highlights
Cyclic voltammograms were recorded at a scan rate of 100 mV × s−1, using a traditional one-compartment three electrode electrochemical cell consisting of two gold electrodes and an Ag|AgCl, KClsat reference electrode
The administration of gold nanoparticles as a tonic and/or for antibacterial purposes can lead to unknown interactions with consequences that are difficult to understand
By the action of halide ions, gold nanoparticles can dissolve; chemical interactions between them can be spontaneous leading to the formation of potentially toxic chemical species
Summary
Vitamin B6 (other names: pyridoxine, pyridoxol, pyridoxine hydrochloride) belongs to the group of soluble B vitamins that are involved in metabolic processes and plays an important role in human health and especially in DNA repair, for which it is an essential cofactor [1]. It is involved in the pathways of methyl-group metabolism as a cofactor for different important enzymes, being a protective nutrient for pancreatic cancer by preventing the alteration of the DNA methylation mechanism [2].
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