Abstract
Drosophila melanogaster ring-X males carrying a double marked Y chromosome, B sY y +, were treated with MMS or DMN and mated with repair-proficient females or the repair-deficient females mei-9 a and st. mus302. Frequencies of induced complete loss (principally the ring-X) and partial losses of the Y chromosome (loss of B s or y +) decreased in the sequence st mus302> mei-9 1>repair-proficient females agreeing with the sequence obtained previously with procarbazine and DEN. With MMS and DMN, some 30–40% or more of partial Y chromosome losses are mosaics from mei-9 a and only 0–4% from st mus302 females suggesting rapid finalization of breaks/pre-break lesions in st mus302 females and a delay in mei-9 a females. Similar findings with procarbazine and DEN are indicated. That the higher sensitivity of st mus302 relative to mei-9 a results from impairments in both postreplication and excision repair in the former remains to be determined.
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