Abstract
To determine whether induced abortion (IA) increases breast cancer (BC) risk. A population-based case-control study was performed from Dec, 2000 to November, 2004 in Shanghai, China, where IA could be verified through the family planning network and client medical records. Structured questionnaires were completed by 1,517 cases with primary invasive epithelial breast cancer and 1,573 controls frequency- matched to cases for age group. The information was supplemented and verified by the family planning records. Statistical analysis was conducted with SAS 9.0. After adjusting for potential confounders, induced abortions were not found to be associated with breast cancer with OR=0.94 (95%CI= 0.79-1.11). Compared to parous women without induced abortion, parous women with 3 or more times induced abortion (OR=0.66, 95%CI=0.46 to 0.95) and women with 3 or more times induced abortion after the first live birth (OR=0.66, 95%CI =0.45 to 0.97) showed a lower risk of breast cancer, after adjustment for age, level of education, annual income per capita, age at menarche, menopause, parity times, spontaneous abortion, age at first live birth, breast-feeding, oral contraceptives, hormones drug, breast disease, BMI, drinking alcohol, drinking tea, taking vitamin/calcium tablet, physical activity, vocation, history of breast cancer, eating the bean. The results suggest that a history of induced abortions may not increase the risk of breast cancer.
Highlights
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in female worldwide, accounting for 23% (1.38 million) of the total new cancer cases and 14% (458, 400) of the total cancer deaths in 2008
The results suggest that a history of induced abortions may not increase the risk of breast cancer
The proportion of induced abortion was higher in the group whose age at first live birth was smaller, and 79.2% of the women whose age at first live birth were before 25 years old reported ever having had an induced abortion
Summary
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in female worldwide, accounting for 23% (1.38 million) of the total new cancer cases and 14% (458, 400) of the total cancer deaths in 2008. The potential causes of breast cancer remain unclear, despite intense studies were conducted in the world. Numerous epidemiological studies over the last decade worldwide have revealed a number of risk factors associated with breast cancer and most of them have produced evidence on the association of reproductive factors with breast cancer risk (Hulka et al, 2001; Hadjisavvas et al, 2010; Jemal et al, 2010). The main reasons are reproductive factors might related to other multiple factor, which might unidentified underlying causal factors and might be weakly related to the risk of breast cancer
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