Abstract
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control. All rats were treated for 5 weeks. Systolic blood pressure (SBP) and heart rate (HR) were measured. LV morphology, function and performance were assessed by histological staining and echocardiography. Serum and cardiac superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were assessed. Cardiac superoxide and hydrogen peroxide (H2O2) productions, protein expressions of SOD2, SOD3, NOX1, NOX2 and NOX4 were also determined. We found that SBP and HR were significantly decreased in SHRs-treated group. Echocardiography showed that CJID significantly improved LV morphometry and function. CJID decreased MDA level, but increased SOD activity. Cardiac superoxide and H2O2 generation were decreased in SHRs-treated group. CJID caused cardiac SODs expressions to be increased but NOXs expressions to be suppressed. In conclusion, CJID prevents H-LVH by reducing reactive oxygen species production via the NOXs-dependent pathway.
Highlights
Hypertension sets to become a vital factor in health worldwide, since it causes increase in death rate and disability among people in many countries [1]
This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stressrelated cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4
After treatment for 2 weeks, Systolic blood pressure (SBP) was significantly lower in SHRs and it continued to decrease in subsequent weeks by 6.7%, 6.8%, 22% and 24.2%, respectively until end of study (P < 0.01)
Summary
Hypertension sets to become a vital factor in health worldwide, since it causes increase in death rate and disability among people in many countries [1]. A well-recognized risk of cardiovascular-related death is left ventricular hypertrophy (LVH) [2]. LVH is a sensitive indicator of early alteration in the heart because of pressure overload in hypertension [6, 7]. It is an important risk factor of coronary heart disease, heart failure and stroke in patients with hypertension [3, 8]. Recent studies have shown that LVH can increase cardiac-related death [9]. The improvement of cardiac performance can be reached by inhibition of LVH independently of other risk factors [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
