Abstract
Five models of Indonesian H274Y mutant neuralminidase type 1 (N1) were generated from the template 3CKZ by homology modeling. The template has the best similarity percentage 97% with the model sequence. The models was evaluated to search the best model with DOPE, 3D-profiles and PROCHECK in a good rank. The results show model 3 as a potential model to be used in the simulation with the lowest DOPE score, highest verify-3D score and from Ramachandran plots we inferred that it also shared the 1st rank with model 4 based on the 99.4% of the residues found, without Glycine and Proline, at the most favoured and additionally allowed region of both model structures.
Highlights
The H5N1 avian influenza virus is a tremendous threat for a country with an economical background in poultry farming
Recent infections of humans with H5N1 avian influenza viruses have rising the popularity of this type of influenza
The comparison of H5N1 NA sequences with a H274Y mutation from Indonesia with other NA sequences from several pandemics had an objective to see the evolution link and relationship between them
Summary
The H5N1 avian influenza virus is a tremendous threat for a country with an economical background in poultry farming. If spread of the avian influenza virus (AIV) is left untreated, the poultry industry in a certain country could be disastrous. Indonesia is one of the countries that were impacted as a result of this pandemic. In poultry alone, it took down poultry in 31 of 33 provinces [1]. Until 21st April 2010, there were 163 human cases with 135 deaths [2]. By this time, the virus had showed its virulence and the resulting high mortality rate. The toll taken by avian influenza virus was correlated with the pathogenicity of this virus
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