INDOMETHACIN (INDO) PROPHYLAXIS AND OUTCOME AT SCHOOL AGE. † 2222

Abstract

We determined the outcome at school age of children who received INDO for intraventricular hemorrhage (IVH) prevention. Follow-up data were available in 81 children, through developmental testing (n=46) or through completed questionnaires (n=35). Of 81, 26 received INDO; 55 did not (NO-INDO). Thetable shows demographics and outcomes as to school performance, severe neuro/sensory handicaps, and in those tested using the WISC-III, the means of the IQs; i.e., verbal (VIQ), performance (PIQ), full scale (FSIQ), verbal comprehension (VC), perceptual organization (PO), freedom from distractibility (FD), and processing speed (PS). Multiple linear regression was used to determine the effect of birth weight (BW), socioeconomic status (SES), IVH grade and indomethacin, on full scale, verbal and performance IQs, as well as on the 4 factors. We found no differences in outcomes between the INDO and NO-INDO groups. IQ scores were not related to INDO, BW or SES. However, FSIQ was related to sex (p<0.005) and IVH(p<0.02). Verbal IQ was related to sex but not to IVH. PIQ and POIQ were significantly related to IVH (p<0.02). We conclude that INDO for IVH prevention did not affect long-term outcome, however, IVH significantly influenced perceptual organization.