Abstract
The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives. Here we present a data that show interaction drugs based on indolocarbazole derivatives with several intracellular targets and consequently activation different pathways of cell death. Also we present results of our studies on the mechanisms of antitumor action of compounds LCS-1006 and LCS-1208 synthesized in the N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia.
Highlights
The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives
We present a data that show interaction drugs based on indolocarbazole derivatives with several intracellular targets and activation different pathways of cell death
We present results of our studies on the mechanisms of antitumor action of compounds LCS-1006 and LCS-1208 synthesized in the N
Summary
The paper discusses the possible mechanisms of antitumor action of indolocarbazole derivatives. Поэтому установление механизмов гибели опухолевых клеток при действии индолокарбазолов необходимо для поиска производных этого ряда соединений, обладающих оптимальной противоопухолевой активностью при минимальной токсичности. Исследование механизма действия способствует тому, что такие привилегированные элементы химической структуры, как у N-гликозидов индолокарбазолов, могут быть предложены для разработки новых биологически активных соединений.
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