Year-end Sale % OFF 
Abstract
AbstractBeckmann rearrangement of alkylcyclooctenone oximes VIa and VIb gave corresponding nine‐membered lactams 1,3,4,5,8,9‐hexahydro‐3‐methyl‐2H‐azonin‐2‐one (VIIIa) and 1,3,4,5,8,9‐hexahydro‐3‐butyl‐2H‐azonin‐2‐one (VIIIb), respectively. A stereospecific transannular cyclization was induced by mercuric acetate leading to alkyl indolizinones Xa and Xb. Temperature and solvent dependent nmr spectra of the medium ring lactams indicates the stereochemical control is caused by steric interactions of the alkyl side chain. Lithium aluminum hydride reduced Xa/Xb to cis‐octahydro‐6‐methylindolizidine (XIa) and cis‐octahydro‐3‐n‐butylindolizidine (XIb).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
