Abstract
Objectives: A recently established paradigm in immunology indicates that dendritic cells (DCs) expressing IDO are able to suppress T cell responses and promote immunological tolerance. Using the competitive pharmacological inhibitor of IDO, 1-MT, mechanistic studies from a range of mouse models have supported the hypothesis that rapid and selective degradation of the essential amino acid tryptophan is the means by which IDO-dependent suppression of T cell responses functions.
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