Abstract
Photodynamic therapy (PDT) holds the merits of high spatiotemporal precision and minimal invasiveness, emerging as the novel therapy. Herein, two aggregation-induced emission photosensitizers (AIE PSs) named TPA-YD and DPA-YD were synthesized for overcoming the dilemma of aggregation-caused fluorescence quenching (ACQ) of conventional photosensitizers. In comparison with DPA-YD, the addition of the benzene ring in TPA-YD enhanced the D-A strength, improved the AIE effect and reactive oxygen species (ROS) generation efficiency. The prepared TPA-YD nanoparticles (TPA-NPs) was promising candidates for PDT.
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