Indocyanine Green Nanoparticles for Theranostic Applications

Zonghai Sheng,Dehong Hu,Meng He,Miaomiao Xue,Ping Gong,Lintao Cai

doi:10.1007/bf03353743

Abstract

Abstract Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green (ICG) is a near infrared dye that has been approved by Food and Drug Administration (FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles (NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging (fluorescent imaging and photoacoustic imaging) and therapeutics (photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics.

Highlights

Theranostic is coined originally as a term to describe a treatment platform that combines diagnostics with therapeutics [1]
Little number of NPs has been approved by the Food and Drug Administration (FDA) in USA for clinical use as transport vehicles, and few theranostic NPs have entered human use
We will discuss theranostic applications of diverse Indocyanine green (ICG) NPs categorized by different carriers such as silica, calcium phosphate, nanoGUMBOS, gold, PLGA, phospholipid-polyethylene glycol, PLGAlipid NPs, and so on (Table 1), or by different preparing strategies (Fig. 3)

Summary

Introduction

Theranostic is coined originally as a term to describe a treatment platform that combines diagnostics with therapeutics [1]. The prepared ICG NPs have high photostability, thermal stability, long circulation time, and tumor-targeting ability [11], respectively. A large number of review articles describe clinical diagnostic or therapeutic systems of ICG for the treatment of cancer, few articles have focused on ICG NPs capable of simultaneously imaging and treating cancer [12].

Results

Conclusion