Indocyanine Green-Loaded Halloysite Nanotubes as Photothermal Agents.

Abstract

Photothermal nanoparticles with light-to-heat conversion properties have gained interest in recent years and have been used in a variety of applications. Herein, indocyanine green (ICG), which is commonly employed as a photothermal agent suffering from low photostability, was loaded into halloysite nanotubes (HNTs) resulting in photothermal HNT-ICG nanohybrids. The photothermal heating patterns of the prepared photothermal nanohybrids as a result of near-infrared (NIR) irradiation were carefully examined. The nanohybrids reached a temperature of 216 °C in 2 min under NIR light, and in contrast to free NIR, the ICG loaded into HNTs remained stable over 10 heating and cooling cycles. Moreover, HNT-ICG nanohybrids incorporated into polyacrylonitrile (PAN) were electrospun into nanofibers for use as photothermal nanofibers, and composite nanofibers, which heat up to 79.3 °C under 2 min of NIR irradiation, were obtained. To demonstrate the potential of the PAN/HNT-ICG nanofibers as light-activated antibacterial nanofibers, their NIR light-activated killing activity on Staphylococcus aureus (S. aureus) cells has been explored. The composite nanofibers reduced the number of bacteria on their surface by 7log upon 10 min of NIR irradiation. Encapsulation of ICG in HNTs as a carrier has been demonstrated as an effective way to stabilize ICG and incorporate it into materials and coatings without compromising its functionality.