Abstract
Purpose: To understand the pathophysiology of acute multifocal posterior placoid pigment epitheliopathy (AMPPPE).Methods: Indocyanine green (ICG) angiography was used for three patients, four eyes with acute AMPPPE and four eyes with healed AMPPPE.Results: The angiographic photographs demonstrated widespread choroidal hypofluorescence of the active and healed lesions.Conclusions: Although the pathogenesis and histopathology of AMPPPE are unknown, the literature suggests that AMPPPE may represent an inflammatory reaction, possibly a delayed-type hypersensitivity reaction. The ICG choroidal hypofluorescence in AMPPPE is probably due to partial choroidal vascular occlusion secondary to occlusive vasculitis.
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