Abstract

Objective To investigate the clinical application of fimdus fluorescein angiography(FFA) and indocyanine green angiography(ICGA)in age-related macular degeneration(AMD). Methods The FFA and ICGA data of 742 eyes of 375 AMD patients were analyzed and summarized.Restflts In all patients, 504 eyes (67.9%) were atrophic AMD and 238 eyes (32.1%)were exudative AMD. Of 93 exudative AMD eyes simultaneously performed FFA and ICGA, 14 eyes (15.1%)with classic CNV and 79 eyes (84.9%) with occult CNV were found by FFA, 48 eyes (51.6%)with clear boundary CNV were found by ICGA, and there was significantly statistical difference (x2=27.97,P＜0.01 )between them. Feeder vessels of CNV were found in 6 eyes(6.5% )by ICGA, and all were juxtafoveal and extrafoveal. Of 48 eyes with clear boundary CNV, 29 eyes (60.4%)with subfoveal CNV, 12 eyes (25.0%)with juxtafoveal CNV and 7 eyes (14.6%)with extrafoveal CNV. Conclusions Compared with FFA, ICGA may show CNV more clearly and the feeder vessel of CNV,and is more important to the clinical diagnosis and treatment of AMD. Key words: Age-related macular degeneration; Fundus angiography; Indocyanine green; Fluorescein

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