Abstract

The human immune system is thought to have the capacity to make billions of different antibodies. Despite the vast potential for variations, the set of antibodies circulating at any given time is actually quite simple , a new study reports ( Cell Syst. 2021, DOI: 10.1016/j.cels.2021.08.008 ). Albert J. R. Heck of Utrecht University and coworkers used mass spectrometry to monitor individual profiles of the antigen-binding fragments (Fabs) from immunoglobulin G1 (IgG1) antibodies circulating in human plasma. Antibodies are proteins produced by the immune system to recognize and neutralize invaders like bacteria and viruses. IgG antibodies represent about 75% of the serum antibodies in humans and are associated with the so-called adaptive immune response, which is tailored to specific pathogens encountered; IgG1 is the most abundant subclass. The researchers measured the mass and chromatographic retention times of Fabs from samples collected at multiple time points from two healthy people and

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