Abstract
The human immune system is thought to have the capacity to make billions of different antibodies. Despite the vast potential for variations, the set of antibodies circulating at any given time is actually quite simple , a new study reports ( Cell Syst. 2021, DOI: 10.1016/j.cels.2021.08.008 ). Albert J. R. Heck of Utrecht University and coworkers used mass spectrometry to monitor individual profiles of the antigen-binding fragments (Fabs) from immunoglobulin G1 (IgG1) antibodies circulating in human plasma. Antibodies are proteins produced by the immune system to recognize and neutralize invaders like bacteria and viruses. IgG antibodies represent about 75% of the serum antibodies in humans and are associated with the so-called adaptive immune response, which is tailored to specific pathogens encountered; IgG1 is the most abundant subclass. The researchers measured the mass and chromatographic retention times of Fabs from samples collected at multiple time points from two healthy people and
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
