Individualized treatment with multiple antihypertensive agents is often necessary when treating hypertension in obese patients

Abstract

Treatment with a number of antihypertensive agents is usually necessary to achieve blood pressure control in patients with obesity-related hypertension. Diuretics, renin-angiotensin system inhibitors and dihydropyridine calcium channel blockers are commonly used first, with subsequent additions of aldosterone antagonists and/or dual α- and β-blocking agents as necessary. Treatment should be based on an understanding of the underlying mechanisms of obesity-related hypertension, and individualized according to patient characteristics and co-morbidities.