Abstract
Transplanted mature donor T cells play a pivotal role after allogeneic haematopoietic stem-cell transplantation (HSCT). T cells protect patients from viral infections and mediate graft-versus-tumour effects.1 However, T-cell responses can lead to the development of graft-versus-host disease (GVHD). Rabbit anti-thymocyte globulins are polyclonal immunoglobulins obtained from hyperimmune sera of rabbits immunised with human thymocytes (ATG-T) or the human Jurkat T-cell line (ATLG).2 Anti-thymocyte globulin has a half-life of 5–14 days,3 and thus remains present at substantial concentrations at transplantation when given during the conditioning regimen.
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