Abstract
Rats exhibit individual differences in their consumption of sugar and in their response to amphetamine treatments. Intrinsic variation in the functioning of the mesolimbic dopamine system is one potential mechanism underlying the expression of these individual differences. The present experiment examined the relationship between sugar consumption and the dopaminergic response to amphetamine. In vivo microdialysis was used to assess amphetamine-stimulated dopamine overflow in the posterior-medial nucleus accumbens in LOW and HIGH sugar feeders. Sugar consumption correlated significantly with amphetamine-stimulated accumbens-dopamine overflow. HIGH rats exhibited significantly higher levels of amphetamine-stimulated accumbens-dopamine overflow than LOW rats. These results suggest that the propensity to ingest sugar is a predictor of the nucleus accumbens dopaminergic response to amphetamine treatment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
