Individual Differences in Right Dorsolateral Prefrontal Cortex Volumes, Whole Brain Activity and Memory Performance in Healthy Young and Older Adults

Abstract

Event Abstract Back to Event Individual Differences in Right Dorsolateral Prefrontal Cortex Volumes, Whole Brain Activity and Memory Performance in Healthy Young and Older Adults Y. Czechowska1, C L Grady1, 2, R. Languay1, J C Pruessner1, M N Rajah1* and L. Valiquette1 1 McGill University, Douglas Mental Health University Institute, Canada 2 University of Toronto, Rotman Research Institute at Baycrest, Canada We conducted an fMRI study on 25 young and 26 older healthy adults and reported deficits in right dorsolateral PFC (DLPFC) activity that were linked to context memory reductions deficits in older adults (Rajah et al 2010). To extend this result we conducted semi-automatic volume segmentation of left and right DLFPC in this cohort and found a near significant (p = .055) group-by-hemispheric difference in DLPFC volume, due to older adults exhibiting smaller right versus left DLPFC volumes compared to young adults. To determine if this age-difference in right DLPFC volume was linked with changes in right DLPFC structure-function associations, we conducted a multivariate partial least squares (ST-PLS) seed analysis, using right DLPFC volumes and accuracy scores. One significant effect (p<.001) was indentified, which reflected group differences in the network of brain regions activated in association with correct context retrieval and larger right DLPFC volumes. In young adults improved retrieval accuracy and larger right DLPFC volumes was associated with increased bilateral DLPFC activity and right hippocampal activity. In contrast, in older adults retrieval accuracy and larger right DLPFC volumes was associated with increased activity in left, but not right, DLPFC, bilateral ventrolateral PFC and caudate. This supports the argument that age-related deficits in context memory retrieval may be due to changes in right DLPFC structure, function and its structure-function associations with the retrieval network, including right hippocampus. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Cognitive Neuroscience Citation: Czechowska Y, Grady C, Languay R, Pruessner J, Rajah M and Valiquette L (2010). Individual Differences in Right Dorsolateral Prefrontal Cortex Volumes, Whole Brain Activity and Memory Performance in Healthy Young and Older Adults. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00116 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Jun 2010; Published Online: 30 Jun 2010. * Correspondence: M N Rajah, McGill University, Douglas Mental Health University Institute, Montreal, QC, Canada, maria.rajah@mcgill.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Y. Czechowska C L Grady R. Languay J C Pruessner M N Rajah L. Valiquette Google Y. Czechowska C L Grady R. Languay J C Pruessner M N Rajah L. Valiquette Google Scholar Y. Czechowska C L Grady R. Languay J C Pruessner M N Rajah L. Valiquette PubMed Y. Czechowska C L Grady R. Languay J C Pruessner M N Rajah L. Valiquette Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.