Abstract
A versatile high-yielding indium trichloride mediated one-pot regioselective synthesis of spiroxindoles via domino one-pot, three-component reaction of isatins, pyrazoles, and (<i>E</i>-)-<i>N</i>-methyl-1-(methylthio)-2-nitroethenamine is described. This reaction presumably occurs via domino Knoevenagel condensation–Michael addition–intramolecular O-cyclization sequence. The salient features of the methodology are its clean reaction conditions, the eco-friendly medium, low cost, easy isolation, and excellent yields without column chromatographic purification.
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