Indium-Mediated Multicomponent Synthesis of Pyrroles

Abstract

Reported is the indium trichloride mediated multicomponent synthesis of highly substituted pyrroles. The reaction proceeds in one pot and does not require the exclusion of air or moisture. A number of catalysts were investigated and indium trichloride was shown to be superior, although a mixture of Ag(OTf) and Cu(OTf)2 was also efficacious. Under the reaction conditions a terminal acetylenic TMS group is cleaved. This work is an extension of a previous method from the same group for the formation of furans.