Indium(III) Trifluoromethanesulfonate: An Efficient Reusable Catalyst for the Alkynylation-Cyclization of 2-Aminoaryl Ketones and Synthesis of 2,4-Disubstituted Quinolines

Abstract

An environmentally friendly and highly efficient procedure for the preparation of 2,4-disubstituted quinoline derivatives has been developed by a simple alkynylation 13cyclization reaction of 2-aminoaryl ketones with phenylacetylenes in the presence of indium( III) trifluoromethanesulfonate In(OTf)3 under microwave irradiation and solvent-free conditions. This catalyst can be recovered after the reaction and reused efficiently in subsequent runs.