Indirubin-3’-monoxime inhibits platelet activation through suppression of glycoprotein VI-mediated signal transduction and a possible role for ERK

Abstract

intervention followed by 3 to 7 days of washout period. Acupuncture in all groups was implemented at left LI10 with manipulation after insertion, 5min, 10min after insertion followed by needle removal. Microcirculation by laser Doppler perfusion imaging (LDPI) was measured 5minutes before acupuncture till 10minutes after removal of acupuncture. A repeated measures ANOVA was used for statistical analysis. Results: In each group, microperfusion increased by needle insertion was maintained till after needle removal, and different needle size induced different blood perfusion changes, with the increase in ST group significantly higher than SP, DT and DP groups (repeated measures ANOVA, P<0.0001), but there was no significant difference by needling depth. Conclusion: ST intervention induced the greatest blood perfusion changes comparedwith other interventions, but the impact of different needling depths was not clear with blood perfusion changes. Studies investigating other physiological changes than blood perfusion by different acupuncture needle sizes and needling depths are needed. Contact: Xiuyu Zhang, zhangxiuyu6@hotmail.com