Abstract
Indirect Way for the Assay of Captopril Drug in Dosage FormsUsing1,10-Phenanthroline as a Selective Spectrophotometric Agent for Fe(II) Via Homemade CFIA /Merging Zones Technique
Highlights
Arterial high blood pressure is one of the ailment with main diffusion in the world being caused by still unknown agents; some hazard agents partake of the developed of this pathology [1], like age, family history, sedentariness, obesity, stress, high salt intake and alcoholism
The first medication controlled to be used for arterial high blood pressure medication was captopril (CPL); 1-[(2S)-3-mercapto-2-methylpropionyl] Pyrrolidine –2 Carboxylic acid, that refers to the group of angiotensin-converting enzyme (ACE) preventers [2,3]
In order that assert the quality of CPL including pharmaceutical formulations, ease procedures for its analysis in technical and preparation grade sample are important for routine assay, including atomic absorption spectrometry [8,9] differential pulse polarography [10] high performance liquid chromatography [11,12,13,14,15] volumetric titration [16] voltammetry [17] capillary electrophoresis [18] conductometry [19] gas chromatography [20] chemiluminescence systems [21,22,23,24] diffuse reflectance spectroscopy [25] potentiometric titration [26,27,28] spectrophotometry [29,30,31,32,33,34,35,36,37,38,39,40] fluorimetry [41] amperometry [42,43,44] flow injection analysis [23,24,28,45,46,47] are suitable for use in daily assay in dosage forms specifity control laboratories because to the easiness, high repeatability and reproducibility with high sampling per hour, high analytical frequency and the result in diminishing reagents exhausting when compared with batch methods [28,30]
Summary
Arterial high blood pressure is one of the ailment with main diffusion in the world being caused by still unknown agents; some hazard agents partake of the developed of this pathology [1], like age, family history, sedentariness, obesity, stress, high salt intake and alcoholism. The first medication controlled to be used for arterial high blood pressure medication was captopril (CPL); 1-[(2S)-3-mercapto-2-methylpropionyl] Pyrrolidine –2 Carboxylic acid (figure 1), that refers to the group of angiotensin-converting enzyme (ACE) preventers [2,3]. This medication interplays with(ACE) because of it,s affinity with a dipeptide and the sulphydryl class plays a serious part, linkage covalently to the (Zn) atom in the enzyme plus situation. We presented a new flow injection analysis /merging zones technique for indirect estimation of CPL. in fine material and dosage forms using ferric chloride as an oxidizing agent, where ferric ion will be reduced to ferrous ion by thiol drugs (CPL.), the produced Fe(II) forms an orange-red colored product with 1,10-phenanthroline which is determined spectrophotometrically
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