Abstract
The present study aims to develop a swift , simple, accurate and sensitive spectrophotometric method for determination of Ciprofloxacin Hydrochloride ( CPFX ) in pure and pharmaceutical formulations. The suggested method depend on oxidation of CPFX with known excess amount of N-bromosuccinimide ( NBS ) in acidic medium and after reaction is insured to be complete , the surplus NBS is estimated by de colorization of methylene blue dye and measuring the absorbance of surplus dye at 665 nm . A linear calibration curve was obtained over the concentration range 0.5 – 4.5 μg.ml-1 with correlation coefficient of 0.9993 . The molar absorptivity and sandell's sensitivity index values were determined to be 8.6 ×104 L.mol-1.cm-1 and 0.004276 µg.cm-2, respectively .The limit of detection (LOD) and quantification (LOQ) were calculated to be 0.0033 and 0.0111 μg.ml-1, respectively . The proposed method has been successfully applied to the determination of CIPH in available dosage form, the validity proposed method was confirmed by recovery study via standard addition technique .
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
