Abstract
A capillary electrophoretic (CE) method has been optimized for the separation of some common alkali and alkaline-earth metal cations in anti-asthmatic homeopathic liquid pharmaceutical preparations. Separation was carried out on a 74 cm (62.5 cm to the detector) × 75 μm ID fused silica capillary at a potential of 25 kV and 25 °C. Baseline separation of NH4 +, K+, Ca2+, Na+, Mg2+ and Li+ was achieved in less than 4.5 min. The proposed method was applied for the determination of the above-mentioned ions in homeopathic liquid formulations. Limits of quantitation (LOQ) observed were 1.5 ppm for NH4 +, Ca2+ and Mg2+ 0.8 ppm for Na+, 1.6 ppm for K+, and 0.4 ppm for Li+. During electrophoresis, the ingredients used in the preparation of homeopathic formulation did not interfere with the cations examined.
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