Abstract
Concentrations of 5 μg/ml or less of 5-fluorodeoxyuridine (FDU) and of 5-bromodeoxyuridine (BDU) inhibited the growth of adenovirus type 5 and of vaccinia virus in ERK and chick embryo cells, provided that adequate time was allowed for the inhibitors to act. With the same proviso, FDU and BDU also inhibited the growth of ERK cells. Under similar conditions of cultivation, concentrations of up to 100 μg/ml of FDU and of BDU had no effect on the growth of either the New Jersey or the Indiana serotype of vesicular stomatitis virus (VSV) in either ERK or chick embryo cells. It is concluded that virus particles of both serotypes of VSV contain RNA rather than DNA.
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