Abstract

Abruptly increasing [K]o and adding ouabain produce short-term depression and enhancement, respectively, of vascular smooth muscle (VSM) reactivity, presumably as a result of stimulating and inhibiting, respectively, hyperpolarizing electrogenesis. Moreover, the presence of a steady-state level of electrogenesis is implicated by the enhancing effect of ouabain. The results of this study indicate that the extent of these short-term changes in electrogenesis and the level of this steady-state electrogenesis are regulated by small changes in steady-state [K]o within a physiological range, 3--6 mM.

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