Abstract
0049-3848/$ see front matter © 2008 Elsevier Ltd. All rights reserv doi:10.1016/j.thromres.2008.06.005 guinea pig represents a suitable species for in vivo or ex vivo investigation [1–3]. The aggregation patterns observed with guinea pigs in responsiveness to ADP, platelet activating factor and collagen were comparable with those observed with human platelets [4]. Platelets from guinea pigs appeared to resemblemore closely those from humans as compared with those of rabbits, dogs or pigs [5,6]. Moreover, guinea pig platelets have functional receptors for vonWillebrand factor and fibrinogen that are structurally homologous to human platelet glycoproteins Ib, IIb and IIIa [7,8]. So, guinea pigs have been extensively used to study the effect of drugs ex vivo (see for instance [1,2,9– 12]). However, the presence of Fc receptors on guinea pig platelets has not yet been investigated, whereas human platelets express a FcγIIa receptor with low affinity for monomeric IgG but with the capacity to bind IgG aggregates and immune complexes [13,14]. This receptor is likely involved in heparin-induced thrombocytopenia for instance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
