Year-end Sale % OFF 
Abstract
AbstractThe nitrosation of ephedrine and the electrochemical reduction of N‐nitrosoephedrine were investigated by differential pulse polarography and have been optimized in order to attain the optimum analytical signal. Reduction of the N‐nitrosoephedrine was carried out in one irreversible, diffusion‐controlled step using potassium chloride‐hydrochloric acid. In 0.1 M hydrochloric acid the N‐nitrosoephedrine shows a well‐defined reduction peak at −0.77 V (vs. Ag/AgCl/ 3 M KCl). An indirect differential‐pulse polarographic method is described for the determination of ephedrine at levels higher than 2.5 μg per mL of urine. An extraction procedure with C18 cartridge and a fast and easy nitrosation reaction with sodium nitrite in 0.2 M phthalate potassium hydrogen is also described. Determination of 5 μg/mL of N‐nitrosoephedrine in urine samples of 4 mL was possible using the standard addition method, with a relative error of −4.0% and relative standard deviations no higher than 2.1%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
