Abstract
Aim: To compare efficacy of apomorphine sublingual film (APL) and levodopa inhalation powder (CVT-301) for 'on-demand' treatment of Parkinson's disease 'OFF' episodes. Patients & methods: Patient-level data from an APL pivotal study were re-weighted to match average baseline characteristics from a CVT-301 study (SPAN-PD). Placebo-adjusted treatments were compared at week 12. Results: Improvements in predose Unified Parkinson's Disease Rating Scale Part III scores were significantly larger for APL versus CVT-301 at 60min postdose (least squares mean difference-in-difference: -8.82; p=0.002); difference at 30min favored APL but was not statistically significant (-4.46; p=0.103). Total daily 'OFF' time reductions were significantly larger for APL versus CVT-301 (-1.31h; p=0.013). Conclusion: Results suggest APL treatment may lead to improved efficacy versus CVT-301.
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