Abstract
Bio-composite scaffolds were fabricated by impregnating 10, 20, 30, 40 and 50% ZrO2 content with the β-TCP matrix to heal load bearing large size bone defects. The composite scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and mechanical testing. The in vitro degradation of scaffolds was calculated by immersing the samples in phosphate buffer saline for a period of 21 days. Biocompatibility was evaluated by XTT assay using human Osteosarcoma cell line (MG-63). Results include scaffold surface morphology, overall porosity, phase transformation, bonding, compressive strength, biodegradability and cytotoxicity with an increase in ZrO2 percentages. The conclusions proved that β-TCP scaffold with 30% ZrO2 content exhibits the best-required properties for the application in the field of bone tissue regeneration.
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