Indirect atomic absorption spectrometric determination of pindolol, propranolol and levamisole hydrochlorides based on formation of ion-associates with ammonium reineckate and sodium cobaltinitrite

Abstract

A new simple, accurate, precise and sensitive indirect method for the determination of pindolol HCl (1), propranolol HCl (2) and levamisole HCl (3) using atomic absorption spectrometry has been developed. The method is based on precipitation of the ion-associates formed from the reaction of (1), (2) or (3) with ammonium reineckate and/or sodium cobaltinitrite. The solubility of the solid complexes at the optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion-associate were prepared under the optimum conditions and the metal ion content in the supernatant was determined. The method has been used for the determination of 1.14–17.07, 1.18–17.75 and 1.08–16.24 μg/ml of (1), (2) and (3), respectively, using ammonium reineckate, and 1.71–25.60, 1.77–26.62 and 1.62–24.36 μg/ml of (1), (2) and (3), respectively, using sodium cobaltinitrite. The method developed was applied for analysis of bulk drugs and some of their pharmaceutical preparations.