Abstract
Indigenous Method and Safety of Mitomycin C in Refractory Corrosive Esophageal Strictures
Highlights
Caustic esophageal strictures still represent a challenge to endoscopist
This hospital based observational descriptive study was done during april 2011- dec 2012 in Department of gastroenterology, SMS medical college, Jaipur to assess the efficacy of topical mitomycin-C in refractory caustic induced esophageal stricture
The periodic dilatation index (PDI) calculated for 12 weeks following MC application decreased significantly in all the patients
Summary
Caustic esophageal strictures still represent a challenge to endoscopist. Standard treatment is regular esophageal dilatation until the resolution of dysphagia. Caustic strictures require dilations more frequently for a positive clinical response [1]. Frequent dilation may become a selfdefeating cycle in refractory stricture as recurrent trauma to the mucosa, enhance scar formation through enhanced fibroblast proliferation and collagen deposition, and recurrence and potential worsening of the stricture [2,3]. In many cases endoscopic dilatation fails and esophageal replacement is eventually required. Non operative management of refractory stricture is limited. No data available on safety and efficacy of Mitomycin c in refractory strictures
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