INDICES OF VASCULAR - ENDOTHELIAL AND GRANULOCYTIC COLONYSTIMULATING GROWTH FACTORS IN PATIENTS SUFFERING FROM CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT CHRONIC PANCREATITIS IN THE DYNAMICS OF THERAPY

Abstract

Purpose. Estimation of the level of the circulatory vascular-endothelial growth factor(VEGF) and granulocytic colony-stimulating growth factor (GCSF) in patients sufferingfrom chronic obstructive lung disease (COLD) with concomitant chronic pancreatitis(CP) in the dynamics of therapy.Material and methods. Investigation of 52 patients with COLD B-C groups, where theobstruction degree corresponded to COLD 1-2 with a low risk and more pronouncedsymptomatics (B), and also COLD 3 with a high risk but less pronounced symptomatics(C), - I group, 60 CP patients with corresponding characteristics of groups with concomitant COLD (II group) and 19 practically healthy persons as a referent group wascarried out. Patients of II group were divided into 3 subgroups according to theobtained treatment. Patients of IA subgroup (19 persons) received basic therapy according to the MPH order of Ukraine №555 dated from 27.06.2013. 23 patients, whoreceived "Essentsiale forte H" two capsules thrice a day during 1/12, except generallyaccepted treatment, constituted IB subgroup. In patients of IB subgroup (18 patients) thebasic treatment was combined with additional administration of kvertsetin in a dose of1.0 g thrice a day during 14 days.Results. Thus, in patients of II group VEGF level (median and 80% interprocentilerange) was 203 pg/ml [104,3 - 391, 68 pg/ml], that differed from healthy persons (p<0,05).This index fluctuated from 104 to 195, 84 pg/ml, and median was equaled to 172, 92pg/ml in patients without concomitant pathology of the pancreas. In practically healthypersons it constituted 28, 7 [15, 07 - 44, 39] pg/ml accordingly. As to G-CSF its concentration was various in patients of both groups in comparison with the group ofpractically healthy persons. Differences between groups of patients were not revealed.Thus, this index fluctuated from 21 to 93, 3 pg/ml, median constituted 26, 2 pg/ml inpatients of II group, and in patients of III group it was 23-93, 3 pg/ml and median - 27, 9pg.ml.Conclusions. An increase of the circulating VEGF level at COLD exacerbation withconcomitant CP is probably associated with the systemic response syndrome to inflammatory process. CP presence deteriorates the indices of the endothelium functioning.