Indices of endothelial function and their relationships with psychoemotional factors in practically healthy people

Abstract

We studied gender-related traits of indices of endothelial function and their relationships with psychoemotional factors in practically healthy subjects. The study included 107 practically healthy people of working ages from an organized population (46 men and 61 women); the average age was 43.4. ± 10.8 years. All subjects participated in a psychological questionnaire, which included the Spielberg-Khanin test, the Center for Epidemiologic Studies Depression Scale, a modified variant of the Dembo-Rubinstein test, the level of social frustration, and the social readjustment rating scale (Holms and Rahe test). Venous blood was collected to study the indices of endothelial function. In the study, we found a significant correlation between factors of endothelial origins and the level of social frustration, depression, and self-evaluation of stress according to the Dembo-Rubinstein test in practically healthy men. In practically healthy women with normal arterial pressure, trait anxiety positively correlated with markers of endothelial function. According to the data of stepwise regression, the contribution of depression to the level of nitrites in women with normal pressures was 25%. The characters of stress-related changes and concomitant biochemical, hormonal, and morphofunctional changes are substantial for analysis of the mechanisms of the influence of stress on the development and time course of somatic diseases and the development of the psychosomatic approach to the prophylactics of psychosomatic disturbances.