Abstract
Aim . To determine the indices of vascular endothelial growth factor and docosahexaenoic acid in women with threatened early pregnancy associated with cytomegalovirus infection exacerbation. Materials and methods . The study included 74 women at a gestation period of 7-12 weeks, of which 38 women with exacerbation of cytomegalovirus infection and the onset of spontaneous miscarriage (main group) and 36 without such pathology (control group). The material for the study was peripheral blood, urine, and scraping of the buccal epithelium. Antibodies IgM and G to cytomegalovirus, low avidity IgG (avidity index) were determined by enzyme-linked immunosorbent assay. Cytomegalovirus DNA was detected by real-time PCR analysis. Indicators of vascular endothelial growth factor were established by enzymelinked immunoassay. The concentration of docosahexaenoic acid was analyzed using capillary gas-liquid chromatography. Results . The concentration of vascular endothelial growth factor in the blood serum in pregnant women in the main group was 1.7 times (p<0.001) lower than in the control group. A similar dynamics of changes was established for docosahexaenoic acid, the concentration of which was 1.4 times lower than that of the control group (p<0.001). Conclusion . The data obtained indicate that the exacerbation of cytomegalovirus infection in early pregnancy is associated with a significant decrease in vascular endothelial growth factor and docosahexaenoic acid, which has adverse effects on angiogenesis and growth of placenta, and pregnancy outcome.
Highlights
A similar dynamics of changes was established for docosahexaenoic acid, the concentration of which was 1.4 times lower than that of the control group (p
Lebold K.M., Kirkwood J.S., Taylor A.W., Choi J., Barton C.L., Miller G.W., La Du J., Jump D.B., Stevens J.F., Tanguay R.L., Traber M.G. Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos // Redox Biol
Summary
ПОКАЗАТЕЛИ СОСУДИСТО-ЭНДОТЕЛИАЛЬНОГО ФАКТОРА РОСТА И ДОКОЗАГЕКСАЕНОВОЙ КИСЛОТЫ У БЕРЕМЕННЫХ ЖЕНЩИН С УГРОЖАЮЩИМ ТЕЧЕНИЕМ БЕРЕМЕННОСТИ РАННИХ СРОКОВ, АССОЦИИРОВАННЫМ С ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИЕЙ. Определить показатели сосудисто-эндотелиального фактора роста и докозагексаеновой кислоты у женщин с угрожающим течением беременности ранних сроков, ассоциированным с цитомегаловирусной инфекцией в стадии обострения. Полученные данные свидетельствуют, что обострение цитомегаловирусной инфекции на ранних сроках беременности ассоциировано со значимым уменьшением показателей сосудисто-эндотелиального фактора роста и докозагексаеновой кислоты, имеющим неблагоприятные эффекты на ангиогенез и развитие плаценты, исход беременности. Показатели сосудисто-эндотелиального фактора роста и докозагексаеновой кислоты у беременных женщин с угрожающим течением беременности ранних сроков, ассоциированным с цитомегаловирусной инфекцией // Бюллетень физиологии и патологии дыхания. Цель исследования – определить показатели VEGF1 и докозагексаеновой кислоты (ДГК) у женщин с угрожающим течением беременности ранних сроков, ассоциированным с ЦМВИ в стадии обострения
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