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Abstract
The results of the analysis of the bronchial hyperreactivity indicators in 60 children suffering from asthma with exercise induced bronchoconstriction and without exercise induced bronchospasm are presented in the article. It has been established that higher bronchial lability was typical for children with asthma and exercise induced bronchoconstriction. The bronchial hypersensitivity to inhaled histamine in a concentration less than 0,4 mg/ml with 77 % specificity, 71 % post-test probability and significant odds ratio indicate a phenotype of childhood asthma with exercise induced bronchoconstriction.
Highlights
Bronchial asthma (BA) is considered to be a multifactorial disease characterized by recurrent episodes of reverse variable bronchial obstruction, which are based on the increased airway hyperresponsiveness (AHR) to various stimuli [5, 6]
The significant difference between the values of the dilatation of the bronchi in response to the test with inhaled short-acting β2-agonist was revealed in patients of the main group: in children with exercise-induced asthma phenotype IBD and IBL were almost three times higher
Increased bronchial lability (IBL more than 20 %) more frequently was recorded among patients with asthma phenotype accompanied by EIB as compared to the second clinical group (13,3 %, Pφ
Summary
Bronchial asthma (BA) is considered to be a multifactorial disease characterized by recurrent episodes of reverse variable bronchial obstruction, which are based on the increased airway hyperresponsiveness (AHR) to various stimuli [5, 6]. Nonspecific AHR to direct and indirect triggers may be considered as a key phenomenon of asthma, which is the basis of formation of its clinical symptoms, frequency and severity of exacerbations, AHR determines the course, severity, and controllability of the disease in general [8]. Bronchoconstriction caused or induced by exercise (EIB) often manifests among the first symptoms of BA, which may be a possible sign of bronchial hyperreactivity, which, in turn, is a diagnostic marker of BA [2, 4]. There is a lack of scientific research on the evaluation of the diagnostic value of bronchial lability and hyperreactivity for verification of clinical subphenotypes of the different variants of the disease in order to determine the optimal therapeutic approaches in children [12]
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